The Mixture of Gastrodia elata and Glycyrrhiza uralensis Attenuates Scopolamine-Induced Cognitive Disorder

Background: Cognitive disorders are symptoms of degenerative neuronal diseases such as Alzheimer’s disease (AD). This study evaluated the effects a mixture Gastrodiae elata (GE) and Glycyrrhizae uralensis (GU) (GGW) on scopolamine-treated cognitive function in vivo. Methods: To induce memory impairment disorder, C57BL/6 mice were intraperitoneally administered scopolamine. In experimental period, Y-maze, passive avoidance, water maze tests carried out to measure ameliorative effect GGW disorder. The expression amyloid-β (Aβ), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE) hippocampal tissues measured. addition, assess brain tissue, stained using hematoxylin eosin (H&E). Results: treatment improved latencies maze, avoidance compared with scopolamine alone. administration downregulated Aβ AChE expression. BDNF was upregulated by administration. Conclusion: These results suggest that ameliorates impaired scopolamine-induced mouse model. could control pathway regulating Aβ, AChE, BDNF. be used agent for dysfunction.